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The hole story
The evidence indicates that liraglutide remains effective in pediatric obesity, including adolescents and younger children, and that orforglipron produces clinically meaningful weight or HbA1c reductions in adults with obesity or early type 2 diabetes (Kelly et al., 2020), (Fox et al., 2025), (Wharton et al., 2023), (Rosenstock et al., 2025)
It pumps out inflammatory molecules IL-6, TNF-alpha, and IL-1 the very same molecules that drive rheumatoid arthritis, psoriatic arthritis, lupus, and even osteoarthritis
Treatment is often initiated at a high dose, followed by a maintenance dose given less frequently, as determined by the patient's B12 levels and clinical response
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