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Novo Nordisk company announcement, 18 December 2025

In clinical studies with adults with type 2 diabetes, Bydureon BCise lowered A1C by an average of 1.1 to 1.4% from an average starting A1C of 8.4 to 8.5%

Although past meta-analyses reported substantial reductions in MACE with DPP-4 inhibitors [23], their conclusions were based on studies with small sample sizes and limited numbers of cardiovascular events, which have not been confirmed by the four CVOTs specifically designed to assess the CV safety of DPP-4 inhibitors

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First-to-file Paragraph IV challengers capture disproportionate value in the immediate post-expiry period