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Avoid high-volume, high-intensity cardio that significantly increases your calorie deficit beyond what the medication already creates
Doses above 2ml per injection show no additional methylation benefit in controlled trials and increase injection site discomfort without improving fat mobilisation
If cold sensitivity is particularly troublesome, discussing the rate of weight loss with your healthcare team may be appropriate
Knowing that baseline first is what turns a prescription decision into an informed conversation with your provider
Retrieved August 19, 2025, from Mayo Clinic website
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