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Can use continuously or cycle 12 weeks on, 4 weeks off
Daily application at roughly the same time produces better results than sporadic use even at higher doses
Xie J, Shen Z, Anraku Y, Kataoka K, Chen X
"Effects of topical creams containing vitamin C, a copper-binding peptide cream and melatonin compared with tretinoin on the ultrastructure of normal skin - A pilot clinical, histologic, and ultrastructural study"
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