Looking forward, a comprehensive understanding of DDR pathway rewiring, coupled with integrated omics-based profiling and network-level vulnerability mapping, will be pivotal
Glutathione is a tripeptide molecule that combines three amino acids: cysteine, glycine, and glutamic acid
This narrows arteries, raises blood pressure, and causes damage to organs like the liver, heart, and pancreas
While the protection of normal cells against radiation-induced cell death by ebselen has been attributed to its ability to detoxify cellular/mitochondrial ROS through the GPx mechanism, the molecular mechanism contributing to its radio-sensitization effect in cancer cells is still not fully understood
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