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The DPP-4 inhibitor isoleucin-thiazolidide was found to augment insulin secretion and improve glucose tolerance in association with prolonging the half-life of GLP-1 in lean and obese Zucker rats ( First Clinical Study With DPP-4 Inhibition NVP DPP728 in Animals The first DPP-4 inhibitor which was used in a clinical study in type 2 diabetes was NVP DPP728

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Landscapes Chemical & Material Sciences (AREA) Organic Chemistry (AREA) Chemical Kinetics & Catalysis (AREA) Preparation Of Compounds By Using Micro-Organisms (AREA) Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA) Abstract Provided is a process for preparing L-carnitine or acetyl L-carnitine hydrochloride