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Acta Pharm Sin B
GLP-1RAs vary in their efficacy in reducing HbA1c, magnitude of weight loss, duration of action, dosing frequency, and side effects
Published microarray and RNA-seq studies have documented effects on growth hormone (GH1), pituitary-specific transcription factor Pit-1, ghrelin O-acyltransferase (GOAT), and downstream IGF-1 axis genes
IGF-1 is used to test GH production as its daily curve is more stable growth hormone production fluctuates throughout the day
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