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Efforts to improve potency while retaining the optimal profile led to the most balanced Compound 77 , which combines a methyl-pyridine and methyl-1,3,4-thiadiazole motif, achieving high potency, selectivity, and favorable PK, making it a lead candidate for further evaluation

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PMID 13508735

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Research shows it stimulates the production of collagen types I, II, and III, plus elastin, dermatan sulfate, and decorin all of the structural proteins that keep skin firm