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The clinical features strongly resemble classical EDS (cEDS) with two key differences: (1) the absence of atrophic scarring and (2) autosomal recessive inheritance

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Therapeutic Potential Due to its high affinity for the IGF-1 receptor and the benefits that activation of this receptor can provide, it has been investigated for its ability to treat: Wounds and Injuries: IGF-1 LR3 supports the regeneration of tendons and nerves after injury, potentially speeding recovery and reducing scar formation

Grimaldi, A

Characterization of glucose-insulin responsiveness and impact of fetal number and sex difference on insulin response in the sheep fetus