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As a subcutaneous injection administered weekly, it's critical to follow dosing schedules and site rotation for injections to optimize treatment outcomes

However, this dosing time-dependence is more common amongst drugs with shorter half-lives, such as less than 15 h, whereas oral semaglutide has a long half-life of approximately 1 week [1, 10]

While this method cannot provide single-cell resolution, it detects changes in gene expression with greater sensitivity than snRNA-seq

Using the Wrong Needle Length: For subcutaneous injections, a short needle (like 1/2" or 5/16") is all you need

eClinicalMedicine 69 , 102475 (2024)