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Eryptosis and cigarette smoke Cigarette smoking is well-established as a significant contributor to oxidative stress and systemic inflammation, both of which are key drivers of various pathological conditions, including cardiovascular and pulmonary diseases [232]
Specifically, the inhibition of Nrf2 ubiquitination increases nuclear Nrf2 retention and ARE-Nrf2 binding affinity (Rizvi et al., 2015a)
2019 Oct 1;257:S0165-0327(19)30593-2
Interestingly, despite the lack of consistent actions of metformin in terms of metabolic profiles, treatment with the insulin sensitizer caused a complete normalization of ovarian cyclicity, pointing to a discernible reproductive effect of metformin in some PCOS conditions, in line with clinical literature 68 , although conflictive results have been reported also 69
Abdull Razis, N
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