In general, a missed dose can be administered as soon as remembered, unless it is almost time for the next dose
This is one reason MOTS-c is frequently discussed in longevity, performance, and metabolic-health communities
Low Starting Amount Amount per injection: 2.5 mg 50 units (0.50 mL) on a U-100 insulin syringe Frequency: Once daily, under the skin (subcutaneous) Cycle length: One 5 mg vial = 2 days at the starting amount Sources: [1] Selective small-molecule inhibitors of NNMT reverse high-fat-diet-induced obesity in mice PubMed
The standard initial loading dose is 1,000 mcg administered intramuscularly (IM) once weekly for 4 weeks
Most people absorb enough natural B12 that they dont have to worry about additional supplements, but for those with poor nutrition, stomach problems or cancer, B12 can be hard for the body to process