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BMI 27 plus a related condition (like insulin resistance, prediabetes, or hypertension) may qualify
The medications Wegovy and Ozempic both work by causing the feeling of fullness to last longer after meals, resulting in reduced food intake and weight loss
It is important to note that whilst these mechanisms are biologically plausible, the presence of a theoretical mechanism does not automatically translate to clinical efficacy
Many patients who struggled previously discover underlying factors that were never addressed
A critic to the use of a murine model deficient for intestinal GCG products, would be that other gut hormones might compensate for the lack of a functional GCG gene in that tissue, hence explaining the normalized incretin effect
