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The most common ones include: These side effects are usually temporary
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The trial evaluated retatrutide as an adjunct to diet and exercise in adults with type 2 diabetes and inadequate glycemic control
10.1161/CIRCULATIONAHA.121.053350 141 PiperiC.GoumenosA.AdamopoulosC.PapavassiliouA
In the SURMOUNT-1 trial, tirzepatide showed significant weight loss results in adults without diabetes over 72 weeks (15-21% body weight reduction, depending on dose), while orlistat typically produces more modest results (approximately 3-5% additional weight loss beyond placebo at 1 year)
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