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Science 350:13911396 Yurimoto H, Oku M, Sakai Y (2011) Yeast methylotrophy: metabolism, gene regulation and peroxisome homeostasis

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Treatments counteracting oxidative stress, such as the antioxidant, N-acetylcysteine (NAC), have proven effective in preventing the emergence of behavioural and cognitive disruptions in various models of neurodevelopmental disorders [10, 41,42,43]

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Firstly, excessive accumulation of ROS within mesangial cells under chronic hyperglycemia can lead to cell death by activating mTOR, 66 sirtuin1, 67 and XBP1, 60 resulting in renal dysfunction