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These structural modifications prolong its biological activity compared to native IGF-1
Division of Endocrinology and Metabolism, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, 29 Saemunan-ro, Jongno-gu, Seoul 110-746, Korea
PMID 10027866
Proposed mechanisms include upregulation of the nitric oxide system, modulation of growth factor receptors (including VEGFR2 for angiogenesis), and cytoprotective effects on the GI tract
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