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While the three-dimensional structure of tyrosinase has been crystallized in various species, the human tyrosinase crystal structure remains unresolved

Genetics can also cause high Hcy, with a common mutation in the MTHFR gene increasing the risk of heart disease and blood clots

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In a 26-week rat oral toxicity study, AOD-9604 produced dose-dependent changes in serum osteocalcin (a bone-turnover marker) at week 13, with the direction reversing by week 26