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Biomed Pharmacother 139:111577
Nausea and diarrhea rates are comparable between the two compounds
Tesamorelin is approved as a therapy for patients with HIV whove accumulated excess abdominal fat, but its also prescribed off-label to people seeking reductions in their visceral adiposity, increases in their muscle mass, and improvements in their cardiovascular or cognitive health
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IGF-DES Receptor Binding Specificity Competitive binding and receptor cross-linking experiments confirmed that both IGF-1 and des-(1-3)IGF-1 bind exclusively to the type 1 IGF receptor in L6 myoblasts, rat vascular smooth-muscle cells, and human lung fibroblasts with des-(1-3)IGF-1 demonstrating greater apparent potency in these assays, attributable to its low affinity for the competing 38 kDa IGFBP rather than differences in intrinsic receptor affinity
