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Plasma levels decline with age, which is part of why it became a research target for skin, hair, and wound healing
Without adequate B12, your bodys ability to produce energy diminishes, leaving you feeling fatigued and sluggish
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Chronic inflammation is probably the biggest driver, whether from gut infections like SIBO or candida, autoimmune conditions, or persistent immune activation
J Neurosci 23:508895, PMID: 12832532 Dallas M, Boycott HE, Atkinson L, Miller A, Boyle JP, Pearson HA, Peers C (2007) Hypoxia suppresses glutamate transport in astrocytes
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