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When They Should Not Be First-Line Therapy Despite their efficacy, novel weight loss peptides should generally not replace GLP-1 or GIP receptor agonists as initial therapy for uncomplicated obesity
In high-fat-diet rodent models, changes in body mass or adipose-tissue measurements may reflect the experimental metabolic endpoint being studied, but safety interpretation is stronger when paired with food intake, body composition, activity, general observations, serum chemistry, hematology, organ weights, and histopathology
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