Furthermore, neuroinflammation driven by systemic oxidative stress disrupts the delicate balance of autonomic signaling in the brain, leaving patients stuck in a perpetual, exhausting 'fight or flight' state
Cyclosporine slows down the growth of certain immune cells
However, some patients experience significant side effects, including nausea, vomiting, or gastrointestinal discomfort
This impairment can lead to neuronal damage and increased A accumulation, a key feature of AD pathology [14, 15]
It is pharmacokinetically puzzling as an oral therapy because, as a peptide, it faces the usual hurdles of gastric degradation and poor epithelial uptake