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Some patients with obesity and metabolic syndromethe population commonly prescribed tirzepatidemay have underlying inflammatory conditions that coincidentally become apparent during treatment
the magnitude of HbA1c change in this non-diabetic population was modest, as would be expected Fasting insulin levels decreased, indicating improved insulin sensitivity Triglyceride and lipid profiles showed favourable changes, which may reduce cardiometabolic risk Waist circumference was substantially reduced, reflecting a decrease in visceral (abdominal) adiposity These findings are particularly relevant given that excess visceral fat is strongly associated with type 2 diabetes, cardiovascular disease, and metabolic syndrome
In thinking about GLP-1 medications and lean mass, the first myth we need to clarify is: Weight Loss Just Fat/Adipose Tissue Loss Any time the body loses weight, it loses a combination of: Adipose/fat mass Lean mass (including skeletal muscle) Research on GLP-1 RAs suggests that while a significant portion of weight loss comes from fat, a meaningful percentage can also come from lean mass (upwards of 40%)
doi: 10.6065/apem.2017.22.3.145 46 KopchickJJBerrymanDEPuriVLeeKYJorgensenJOL
BCBS of Massachusetts and the Federal Employee Program (FEP) generally offer broader anti-obesity medication coverage, while other affiliates may limit coverage to non-GLP-1 options
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