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also showed significant increases in serum concentrations of asymmetric dimethylarginine (ADMA), enhanced inhibition of NOS, enhanced catabolism of Arg, increased levels of ornithine (Orn) and proline (Pro), and decreased Arg/Orn ratio in patients with asthma and obstructive sleep apnea (OSA)

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By using polar hydrophilic prodrugs, we are able to demonstrate that hArg-Amp show little release via the IN (intransal) or IV (intravenous) route yet still maintain a similar AUC

Subcutaneous injection into fatty tissue is standard for most peptides

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