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GLP-1 medications cause constipation by slowing gastric emptying and overall gut transit time Macrogol preparations retain water in stool and are recommended for long-term use with GLP-1 therapy Bulk-forming laxatives like ispaghula husk are first-line treatment according to NICE guidance Adequate hydration (1.52 litres daily) is essential when using laxatives with GLP-1 medications Patients should seek medical advice if constipation persists beyond 12 weeks despite treatment Table of Contents Have questions about Wegovy

Symptoms That May Indicate Nerve Health Problems You may require nutritional nerve support if you experience: Tingling sensation Numbness in hands or feet Burning pain Weakness Fatigue Poor concentration Muscle cramps Loss of sensation Nerve discomfort Always consult a healthcare professional for proper diagnosis and treatment

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The newer development is understanding that glycine, not just cysteine, is also rate-limiting with age

10.12688/f1000research.19139.1 45 JiY.LiM.ChangM.LiuR.QiuJ.WangK.et al (2022)