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This ERK-MAPK inhibition is closely associated with suppressed colon cancer cell proliferation [59]

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Animal Model:Male Sprague-Dawley rats weighing 300 to 350 g with glucose IV at a variable rate for 7 hours to maintain plasma glucose concentration at 11 mM [2]

These findings point to both mechanistic changes at a cellular and receptor level and to clinically measurable outcomes such as reduced cravings and decreased meal intake