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The study concluded that in newborn rats, the activation of the c-Fos gene worked to increase body weight, while at more advanced ages the treatment led to a decrease in body weight and an increase in uncoupling protein 1
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A striking and still unresolved observation is that the most vulnerable neuronal populations differ markedly across disorders, affecting distinct brain regions such as the hippocampus in AD, the substantia nigra in PD, or the motor cortex and spinal cord in ALS
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