With B12 injections, you also have to be careful not to inject them into a vein
Someone with mild symptoms and a gut condition may still need injections, while someone with lower numbers and healthy digestion may respond well to oral B12
Oral supplements have not worked for you, which is common when an absorption problem is the underlying cause
For more details on homocysteine, see the article: Homocysteine and Vitamin B12 The Steps of the Methionine Cycle Step 1: methionine is converted into SAM by the enzyme methioninadenosyltransferase (MAT) in the presence of magnesium (Mg) and ATP (universal energy donor)

External resources PubMed - Search for "AOD 9604" or "tirzepatide" to access original research papers, systematic reviews, and clinical trial data from peer-reviewed journals ClinicalTrials.gov - Official registry of all ongoing and completed tirzepatide clinical trials including the full SURMOUNT and SURPASS programs FDA Drug Safety and Availability - Official safety communications, prescribing information, and regulatory updates for Mounjaro and Zepbound (tirzepatide) New England Journal of Medicine - Published the primary SURMOUNT-1 trial results and other landmark tirzepatide studies The Obesity Society - Evidence-based clinical guidelines and educational resources on pharmacological approaches to obesity management SeekPeptides provides calculators, protocol guides, and comparison tools that help users work through exactly these kinds of decisions with data rather than guesswork