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PMID 15609471

Neuropharmacology 128, 142151

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So far, serious side effects havent been common, but heres what an early phase 2 study has shown: Pancreatitis: Happened in about 0.4% of people in the study Gallbladder problems: Reported in about 1.1% of participants Heart rhythm changes: Seen more often with retatrutide, about 6% compared to 3% with placebo Liver enzyme changes: Around 1% of participants had increases, but overall liver health stayed stable These results suggest a low but real chance of serious issues such as pancreatitis, gallbladder problems, severe GI events, and allergic reactions