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LPS has a broad spectrum of negative health effects in the body ranging from inflammation to cancer promotion ( Another member of the TLR family, TLR5, plays a critical role in antigen recognition, specifically bacterial flagellin, while other roles include preserving barrier function in the gut ( An enzyme intricately linked to endotoxemia is intestinal alkaline phosphatase (IAP), as it is involved in the detoxification of LPS ( via chylomicrons, leading to improved lipid profiles and liver steatosis scores ( 3.2 Intestinal Inflammation A healthy intestinal tract requires efficient tolerance signals to modulate and suppress inflammatory responses resulting from exposure to an overwhelming number of commensal bacteria, potential dietary antigens, and various ubiquitous enteric pathogens

384(26): 24912492." Accessed on April 3, 2024, at PubMed Central (PMC) - "J Nephrol Ther

GLP-1 is a hormone produced and secreted by intestinal enteroendocrine L cells and certain neurons upon food consumption, which decreases blood glucose by enhancing insulin secretion, reducing glucagon concentrations, and delaying gastric emptying

TGR5 and FXR are expressed in enteroendocrine L-cells in the intestine