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Aerobic exercises (e.g., swimming, walking, cycling), appear most effective for helping move stool through the colon

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To prevent this degradation, we replaced Ala of xGLP-E4 with a Ser residue

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Via the catalytic activity of a broad superfamily of phase II detoxification enzymes, the Glutathione STransferases (GSTs), glutathione is covalently conjugated to electrophilic xenobiotics and endogenous reactive intermediates

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These effects are similarly observed in FXa-resistant PAR2-G37I mice, suggesting cell-autonomous, autocrine FXa-PAR2 signaling

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