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People often describe cold hands and feet, chills, or feeling colder than others in the same room

Clinicians should consider integrated plans that include nutritional counselling and exercise recommendations alongside pharmacotherapy

Liraglutide, for example, was shown to reverse sirtuin 1 (SIRT1), NOX4 levels, and ROS generation by modulating TNF- and SIRT1/NOX4/ROS pathway in the hypoxia-induced H9c2 cells, thereby suppressing the NLRP3 inflammasome-dependent cellular pyroptosis

All authors have made significant contributions to this study and have approved the final manuscript.

As such, it is commonly used to aid in the management of type 2 diabetes and obesity-related medical conditions