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The improvement in HbA 1c following GLP-1 RA may primarily be driven by weight loss [50], but the mechanism may be more nuanced in individuals with type 1 diabetes and normal body weight
August PJ, Ferguson JE, Madan V
10.1371/journal.pbio.1001843 PLoS Biol
[27] on the antidiabetogenic effect of intestinal factors, and in 1929 by Zung & La Barre [28] on the release of a substance from intestinal mucosa with properties to decrease glycaemia, signalled the start of the development of the incretin concept and the study of the relationships between the gut and the endocrine pancreas
A summary of relevant scientific data
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