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Larsen, A
GLP-1 and GIP receptors are expressed in regions including the hypothalamus, hindbrain, and area postrema, and tirzepatide is used as a tool compound to probe how dual receptor engagement modulates neuronal firing, appetite-related gene expression, and neuroinflammation markers in cell and organoid systems
However, separate research using a GLP-1 drug called liraglutide showed nearly 50 percent brain volume loss and an 18 percent slower decline in cognitive function in people with Alzheimer's in December
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