In PsO, clinical studies evaluating GLP-1RAs such as liraglutide and semaglutide have reported significant improvements in PASI scores and histopathological skin features, effects that appear to be at least partially independent of weight loss ( Given the prominent role of IL-17driven inflammation in obese PsA patients, GLP-1RAs may also enhance the efficacy of biologic agents targeting these pathways
Its a key player in regulating our metabolism
- Tirzepatide Once Weekly for the Treatment of Obesity (SURMOUNT-1, NEJM 2022, n=2,539) Semaglutide Prescribing Information (FDA, 2025) Tirzepatide Prescribing Information (FDA, 2025) Self-Monitoring via Digital Health in Weight Loss Interventions: A Systematic Review Among Adults with Overweight or Obesity What Real Weight Tracker Users Say About Staying With It The Scale Matters Less When the Whole Week Makes Sense A weight loss tracker app only matters if it keeps someone going past week one
Several documented and mechanistic considerations are of particular concern
Headaches and Lightheadedness A small number of people find they experience a mild headache or a sense of lightheadedness when they first begin a glutathione routine