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Compared to the former speculation, another study found that adipocytes can secrete specific fatty acids to induce ferroptosis resistance in breast cancer cells, and this process was dependent on the fatty acid synthetase ACSL3, confirming that breast cancer cells co-cultured with peri-tumor adipocytes showed resistance to ferroptosis (82)
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Indeed, metabolic pathways that reside in the mitochondria, endoplasmic reticulum, lipid droplets, peroxisomes and other organelles all contribute to the regulation of ferroptosis sensitivity
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