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Because IGF-1 is normally found at low levels in MetS and T2D, maybe because of insulin cessation to inhibit IGFBP-1 production by the liver and because of decreased liver IGF-1 secretion by insulin stimulation, as insulin resistance prevails in the liver
J Clin Invest 2023;133:e167700.ArticlePubMedPMC 31
Five half-lives is the standard pharmacokinetic benchmark for clearing a drug from the system
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