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Along with physical disabilities and psychological issues, there is a considerable increase in the risk of diabetes, cancer, and cardiovascular diseases associated with obesity [51]

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2 The more frequent events included nausea, vomiting, diarrhea, and constipation compared with placebo

Although various adverse side effects, including gastrointestinal disturbances, sagging jowls, sulfurous burping and other issues have been reported among GLP-1 users, there has been limited research or reporting about their potential impact on smell and taste perception

Because retatrutide adds glucagon receptor activation, it requires close tracking of transient heart rate changes, and early data suggests its gastrointestinal side effects may occur slightly more frequently at the highest clinical doses