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Effect of caloric restriction on base-excision repair (BER) in the aging rat brain

If classified as a generic (rather than a biosimilar likely dependent on whether the drug is synthetic or recombinant), Canadian pricing regulations could require discounts of up to 75% relative to originator products, unlocking new potential for public and private payers to cover the drug at scale

Lange, K

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IGF-1 LR3 is engineered with an N-terminal extension and Arg3 substitution that reduces IGFBP-3 binding, extending its effective activity substantially longer in preclinical models