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The rapid rise of GLP-1 therapies has not been without concern

It is a natural source of glutathione as it contains antioxidants and healthy fats

Lean, metabolically healthy profiles use roughly 0.3 to 0.5 mg because exposure and heart-rate sensitivity are higher at the same nominal dose. These sub-1 mg ranges are modeled rather than outcome-tested

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The randomized and double-blinded study compared the effect of weekly semaglutide 2.4 mg plus IBT against placebo plus IBT over 68 weeks