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In previously published protocols different types of derivatization reagents (CMQT or CMLT), different pH of the buffer used in the protocols (7.4) and shorter time of sample reduction and derivatization (3 min) were applied (Tables 3 and 4.) Changing the conditions of reduction and derivatization increases the efficiency of this process, which may give higher final concentrations of the analytes

It may boost energy levels as it increases the amount of fuel availability that the heart requires to function.3 In a systematic review by the Mayo Clinic, carnitine was associated with a 27% reduction in all-cause mortality.3 L-carnitine may also play a role in keeping cholesterol levels in a healthy range.4 How does L-carnitine work

This modest reduction in HbA1c is probably explained by the modest degree of hyperglycemia present in the prediabetes subjects whose baseline mean HbA1c was only 5.95%

JSS is supported by the Diabetes Research Institute Foundation

DOI: 10.4093/dmj.2025.0106