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Common Injection Site Reactions with Mounjaro The most frequently reported local skin reactions to Mounjaro include: Erythema (redness) : A localised area of redness surrounding the injection site, typically appearing within minutes to hours after administration Swelling or induration : Mild puffiness or firmness of the skin at the injection site, which may persist for 2448 hours Pruritus (itching) : Localised itching that can range from mild to moderately bothersome Pain or tenderness : Discomfort at the injection site, usually mild and transient Bruising (ecchymosis) : Small areas of discolouration resulting from minor bleeding under the skin Nodules or lumps : Occasionally, small, palpable lumps may form beneath the skin, particularly if the same injection site is used repeatedly According to the Mounjaro Summary of Product Characteristics (SmPC), injection site reactions are classified as common (affecting between 1 in 10 and 1 in 100 people)

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Yes, topical treatments such as hydrocortisone cream or moisturizing lotions can help alleviate mild rashes

This may suggest that acutely other GLP-1R-expressing sites are able to compensate for the loss of GLP-1R signaling, compensation that proves insufficient when LH GLP-1R is silenced in a chronic manner

3F, G), which may have been influenced by food restriction to 90%