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The norleucine-4 modification eliminates the methionine residue susceptible to oxidation, while the D-phenylalanine-7 substitution enhances receptor binding affinity by constraining the peptide backbone in a conformation that favors MC1R interaction
This work, published by Anisimov et al
Liu X, Zhang M, Go VL, Hu S
PT-141 is designed to improve low sexual desire and arousal in women and men by acting on the brains natural pathways that regulate intimacy and motivation
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