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Safety profiles vary significantly : IV administration carries serious risks including anaphylaxis, hepatotoxicity, and potential endotoxin contamination, while oral supplements typically cause only mild gastrointestinal effects like flatulence or loose stools
Thus, long-term use of SGLT-2is may reduce the effect of weight loss
(dulaglutide) 1
Among those who switched therapies, more than 8 out of 10 (81.8%) patients switched to AOM semaglutide
Treatment consists of replacement of kidney tubular losses, symptomatic management of systemic complications, and specific therapy directed at the basic defect, i.e., lysosomal cystine accumulation
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