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doi: 10.1152/physrev.00018.2018 35 CryanJFDinanTG
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[49] In a phase III double-blind, randomized, controlled trial supported by Eli Lilly, nondiabetic adults with a body mass index of 30 or more, or 27 or more and at least one weight-related complication, excluding diabetes, were randomized to receive once-weekly, subcutaneous tirzepatide (5, 10, or 15 mg) or placebo
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Although our previous research has explored the preliminary mechanisms of EA in the hypothalamus SIRT1-mediated homeostatic feeding and the NTS GLP1 -mediated reward feeding [29, 30], the specificity related to the functional connectivity between neural nuclei and the EA effect has not been deeply probed
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