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Pregnant and breastfeeding women are generally advised against using Semaglutide, as its safety during pregnancy has not been established

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The following summary highlights recommendations from the National Institute for Health and Care Excellence (NICE) and a joint advisory from leading U.S

GLP-1 receptor agonists have been associated with increased risk of gallbladder disease (cholelithiasis, cholecystitis) and may worsen symptoms in patients with gastroparesis due to delayed gastric emptying

The intestinal carnitine pool plays an important role in the communication system of the gutorgan axis, and it can directly affect remote organs by remodeling intestinal carnitine metabolism