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In this respect, in mice given oral curcumin (100200 mg/kg) and AFB1 (0.75 mg/kg) for 30 days, the outcome showed that this metabolite mitigated AFB1-induced inflammatory liver injury by inhibiting of NLRP3 inflammasome activation, enhancing phase II AFs detoxifying metabolism, up-regulating of Nrf2 signaling pathway, and preventing the release of pro-inflammatory IL-1/18 (416)

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