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Oxidative stress can increase when free radicals overwhelm antioxidant defences

[13] Individuals with limited dietary variety may benefit from supplementation even if consuming some animal products

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Relative contraindications requiring caution include active or suspected cancer (GHK-Cu promotes angiogenesis with concern about theoretically feeding tumors, though conflicting data shows documented anti-cancer gene expression effects requiring medical supervision), severe organ dysfunction (kidney or liver failure may slow peptide clearance), hemochromatosis or copper overload conditions, autoimmune disorders, and patients on immunosuppressants or blood thinners

Deep, cystic lesions are appearing when you normally get only superficial pimples