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Therefore, CYP2E1 is the primary enzyme contributing to the conversion of APAP to its reactive intermediate along with other P450s, such as CYP1A2 and CYP3A4

This depletion can hinder the liver's ability to detoxify, leading to a buildup of toxins and further health complications

A diet deficient in vitamin K, which can result from decreased overall intake as seen with sick patients given antibiotics that deplete vitamin K-producing bacteria in the GI tract, fat malabsorption, or intravenous diets lacking adequate vitamin K supplementation, can be associated with increased sensitivity to warfarins effects

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