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McClean et al., 2015)

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This is clinically relevant, as IGF-I is generally less reliable of a biomarker for screening adults above 60 years with GHD and is a better screening and diagnostic biomarker in GHD in subjects with disease onset in childhood or early adulthood (86)

Real-world patients also tend to have more lifestyle support, ongoing medical relationships, and gradual dose reductions compared to the abrupt cessation in clinical trials

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