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GLP-1 medications (glucagon-like peptide-1 receptor agonists) are used mainly for weight management and type 2 diabetes

When starting both therapies simultaneously or in close succession, distinguishing which medication causes side effects becomes challenging, potentially complicating management decisions

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Compared with vehicle controls, GLP-1GIPLani yielded more than 5,411 differentially expressed genes (DEGs) in the liver, compared to only 913 and 57 DEGs induced by GLP-1GIP and Lani, respectively (Extended Data Fig